Analysis of an agmatine deiminase gene cluster in Streptococcus mutans UA159.
نویسندگان
چکیده
An operon encoding enzymes of the agmatine deiminase system (AgDS) has been identified in the cariogenic bacterium Streptococcus mutans UA159. The AgDS is regulated by agmatine induction and carbohydrate catabolite repression. Ammonia is produced from agmatine at low pH, suggesting that the AgDS could augment acid tolerance.
منابع مشابه
AguR is required for induction of the Streptococcus mutans agmatine deiminase system by low pH and agmatine.
Acidic conditions and the presence of exogenous agmatine are required to achieve maximal expression of the agmatine deiminase system (AgDS) of Streptococcus mutans. Here we demonstrate that the transcriptional activator of the AgDS, AguR, is required for the responses to agmatine and to low pH. Linker scanning mutagenesis was used to create a panel of mutated aguR genes that were utilized to co...
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عنوان ژورنال:
- Journal of bacteriology
دوره 186 6 شماره
صفحات -
تاریخ انتشار 2004